Taizhou Zecen Biotech Co.,Ltd.
| Payment Terms | L/C, D/A, D/P, T/T, Western Union, MoneyGram |
| Supply Ability | 5000 Set/Sets per Month |
| Delivery Time | 15 workdays |
| Packaging Details | Carton package |
| Name | Lp-pla2 |
| Analyzer | CIA series |
| Luminescent markers | AP(alkaline phosphatase) |
| Calibration | 2-points |
| Calibrator | Free |
| Quality Control | Free |
| Storage | 2-8°C |
| Material | Magnetic beads, calibrators, Anti A/B, controls |
| Validity period | 18 months |
| Precision | ≤8% |
| Brand Name | Zecen |
| Model Number | Lp-pla2 |
| Certification | CE, ISO13485 |
| Place of Origin | China |
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Product Specification
| Payment Terms | L/C, D/A, D/P, T/T, Western Union, MoneyGram | Supply Ability | 5000 Set/Sets per Month |
| Delivery Time | 15 workdays | Packaging Details | Carton package |
| Name | Lp-pla2 | Analyzer | CIA series |
| Luminescent markers | AP(alkaline phosphatase) | Calibration | 2-points |
| Calibrator | Free | Quality Control | Free |
| Storage | 2-8°C | Material | Magnetic beads, calibrators, Anti A/B, controls |
| Validity period | 18 months | Precision | ≤8% |
| Brand Name | Zecen | Model Number | Lp-pla2 |
| Certification | CE, ISO13485 | Place of Origin | China |
| High Light | Lp-Pla2 IVD Products ，CE IVD Products ，Lp-pla2 | ||
CLIA Reagents of Inflammation (Lp-pla2)
Lp-PLA2 is one of the isoforms in the phospholipase superfamily, also known as platelet-activating factor acetylhydrolase, secreted by macrophages, T cells and mast cells in the vascular intima. Lp-PLA2 expression was upregulated in atherosclerotic plaques and was strongly expressed in macrophages in vulnerable plaque fibrous caps.
Lp-PLA2 can hydrolyze oxidized phospholipids in oxidized low-density lipoprotein ox-LDL to generate lipid pro-inflammatory substances such as lysolecithin and oxidized free fatty acids, which in turn produce a variety of atherogenic effects, including endothelial cell death and Endothelial dysfunction stimulates the production of adhesion factors and cytokines. These substances can further generate a self-reinforcing cycle by chemotactic inflammatory cells, producing more pro-inflammatory substances.
Lp-PLA2 released into the blood circulation is mainly combined with apolipoprotein (Apo) B-rich lipoprotein, low density lipoprotein (LDL) accounts for 80%, and the rest is combined with high density lipoprotein (HDL), lipoprotein and polar lipoprotein. Low density lipoprotein (VLDL) binding. In patients with atherosclerotic disease, Lp-PLA2 levels were positively correlated with LDL subfraction levels.
Clinical testing editor broadcast
The detection of Lp-PLA2 has two kinds of activity method and concentration method. Activity methods mainly use high performance liquid chromatography, radioactivity assay and enzymatic hydrolysis of substrates. High-performance liquid chromatography has low sensitivity and is susceptible to interference from various components in blood.
The radioactivity determination method has problems such as radioactive contamination of reagents, low accuracy, and poor repeatability; the enzymatic hydrolysis of substrates mainly relies on imported reagents, which has the problem of high cost. In clinical practice, the main method used to detect the concentration is ELISA. The EUSA method adopts the solid-phase sandwich method, and the standard substance with known Lp-PLA2 concentration and the sample with unknown concentration are added to the microtiter plate for detection.
Lp-PLA2 and biotin-labeled antibodies were first incubated simultaneously. After washing, avidin-labeled HRP was added. After incubation and washing, unbound enzyme conjugates are removed, and then substrates A and B are added, and the enzyme conjugates act simultaneously. produce color. There is a positive correlation between the depth of color and the concentration of Lp-PLA in the sample.
| Test Item | Lp-pla2 |
| Luminescent Principle | Enzymatic chemiluminescence |
| Luminescent Markers | AP(alkaline phosphatase) |
| Specification | 100 Test/Kit for CIA series |
| / | |
| Principle | Sandwich method |
| Component | Magnetic Beads |
| Calibrator Low | |
| Calibrator High | |
| Anti-A/Anti-B | |
| Control 1 | |
| Control 2 | |
| Accessories Required But Not Provided | Substrate |
| Washing solution | |
| Sample material | Serum |
| Storage | 2-8℃ |
Company Details
Business Type:
Manufacturer
Year Established:
2011
Employee Number:
300~500
Ecer Certification：
Active Member
Zecen Biotech CO., LTD., founded in 2011, is a leading Chinese diagnostics manufacturer specializing in in-vitro diagnostics devices and reagents. Zecen focus on the Chemiluminescent immunoassay (CLIA) field. With all products CE marked, our market presence currently spreads from across China to oth... Zecen Biotech CO., LTD., founded in 2011, is a leading Chinese diagnostics manufacturer specializing in in-vitro diagnostics devices and reagents. Zecen focus on the Chemiluminescent immunoassay (CLIA) field. With all products CE marked, our market presence currently spreads from across China to oth...
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