BEIJING TOPWIN TECHNOLOGY CO.,LTD
| Place of Origin | China |
| Certification | ISO,SGS |
| Model Number | 159351-69-6 |
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Product Specification
| Place of Origin | China | Certification | ISO,SGS |
| Model Number | 159351-69-6 |
|
Product Name: |
Everolimus |
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Cas No.: |
159351-69-6 |
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Assay: |
99% |
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In vitro Everolimus exhibits the immunosuppressive activity which is comparable to that of rapamycin. Everolimus competes with immobilized FK 506 for binding to biotinylated FKBP12 and shows the inhibitory effect on a two-way MLR performed with spleen cells from BALB/c and CBA mice with IC50 of 0.12-1.8 nM. [1] Everolimus also shows antiangiogenic/vascular effects in VEGF-induced HUVEC proliferation with IC50 of 0.12 nM and bFGF-induced HUVEC proliferation with IC50 of 0.8 nM, respectively. [2] A recent study shows that Everolimus shows a dose-dependent inhibitory effects on both the total cells and the stem cells from the BT474 cell line and the primary breast cancer cells with IC50 of 156 nM in total cells of primary breast cancer cells and 71 nM in total cells of BT474 cells. In addition, combination treatment with Everolimus and trastuzumab produces the significantly increased inhibition on the growth of cancer stem cells with the inhibition rate increased by more than 50 %. [3] |
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Company Details
Business Type:
Manufacturer,Exporter
Year Established:
2008
Total Annual:
5000000-100000000
Employee Number:
30-50
Ecer Certification：
Active Member
Beijing Topwin Technology Co.,Ltd. is a high-tech enterprise located in Beijing which was built in 2008,specializing in R&D, manufacturing, sales, import and export trade of ... Beijing Topwin Technology Co.,Ltd. is a high-tech enterprise located in Beijing which was built in 2008,specializing in R&D, manufacturing, sales, import and export trade of ...
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