Zhongke Runxin (Suzhou) Biotechnology Co., Ltd
| Payment Terms | T/T,PAYPAL |
| Supply Ability | 1ton/year |
| Delivery Time | 10-20 work days |
| Packaging Details | 1mg/bottle，10mg/bottle |
| Product | Rare Ginsenoside Ck Ginsenoside Compound K |
| Functions | Anti inflammatory agents for treating inflammatory bowel disease |
| Usage Method | Drug formula, health product formula |
| Suitable People | Tumor patients、Sub healthy population |
| Color | White |
| Grade | Medical Grade |
| Storage | Dry and Shade |
| Water Solubility | Water Soluble |
| Shelf Life | 24 Months |
| CAS No. | 39262-14-1 |
| Specification | Purity More Than 80% |
| Molecular Weight | 622.873 |
| Source | Ginseng extract, Total Saponins of Ginseng |
| Molecular Formula | C36H62O8 |
| Density | 1.05-1.1 |
| Brand Name | NUGLY |
| Model Number | CGO/CK |
| Certification | FDA,ISO9001,ISO22000,FSSC22000 |
| Place of Origin | China |
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Product Specification
| Payment Terms | T/T,PAYPAL | Supply Ability | 1ton/year |
| Delivery Time | 10-20 work days | Packaging Details | 1mg/bottle，10mg/bottle |
| Product | Rare Ginsenoside Ck Ginsenoside Compound K | Functions | Anti inflammatory agents for treating inflammatory bowel disease |
| Usage Method | Drug formula, health product formula | Suitable People | Tumor patients、Sub healthy population |
| Color | White | Grade | Medical Grade |
| Storage | Dry and Shade | Water Solubility | Water Soluble |
| Shelf Life | 24 Months | CAS No. | 39262-14-1 |
| Specification | Purity More Than 80% | Molecular Weight | 622.873 |
| Source | Ginseng extract, Total Saponins of Ginseng | Molecular Formula | C36H62O8 |
| Density | 1.05-1.1 | Brand Name | NUGLY |
| Model Number | CGO/CK | Certification | FDA,ISO9001,ISO22000,FSSC22000 |
| Place of Origin | China | ||
| High Light | Biofertilizer Chitosan Oligomer ，Biofertilizer Chitosan Oligosaccharide ，Chitosan Oligosaccharide Light Yellow | ||
High Purity Rare Ginsenoside Ck Ginsenoside Compound K
【Biological activity】
Ginsenoside C-K is a bacterial metabolite of Ginsenoside Rb1.
Ginsenoside C-K exerts anti-inflammatory effects by inhibiting inducible nitric oxide synthase (iNOS) and COX-2.
In human liver microsomes, Ginsenoside C-K inhibits CYP2C9 and CYP2A6 activity with IC50 values of 32.0 ± 3.6 μ M and 63.6 ± 4.2 μ M, respectively.
【Product Specifications Of Rare Ginsenoside Ck Ginsenoside Compound K】
| Appearance | White powder |
| Other Name | Medical grade Compound K |
| Applicable objects | Tumor patients |
| Product form | Powder |
| Purity | 80% |
| Deacetylation degree | >90% |
| Viscosity (5%) | <10cps |
| Molecular weight | Around 600DA |
| loss on drying | <10% |
| residue on ignition | <1% |
| insoluble | <1% |
| pb | <2ppm |
| As | <1ppm |
| total plate count | <1000 cfu/g |
| mole and yeast | <25 cfu/g |
| E. coli | Negative |
| particle size | >80 mesh |
【In vitro research Of High Purity Rare Ginsenoside Ck Ginsenoside Compound K】
Ginsenoside CK, a bacterial metabolite of G-Rb1, exhibits anti-inflammatory effects mainly by reducing inducible nitric oxide synthase (iNOS), cyclooxygenase-2 (COX), and pro-inflammatory cytokines.
Ginsenoside CK inhibits the expression of pro-inflammatory cytokines by downregulating the activities of IRAK-1, MAPK, IKK - α, and NF - κ B in LPS treated mouse peritoneal macrophages. Ginsenoside CK also inhibits the expression of iNOS and COX-2 by suppressing NF - κ B signaling in RAW264.7 cells stimulated by LPS.
In bone marrow-derived macrophages (BMDM) and RAW264.7 cells treated with yeast polysaccharides, ginsenoside CK inhibits inflammatory responses by negatively regulating the secretion of pro-inflammatory cytokines, activation of MAPK, and production of ROS. In addition, anti-inflammatory activity of ginsenoside CK was observed in LPS stimulated microglia.
Ginsenoside CK inhibits inflammatory responses by controlling the production of ROS and the activity of MAPKs, NF - κ B, and AP-1.
Ginsenoside CK is the main metabolite of ginsenosides in the gastrointestinal tract, which inhibits NF - κ B signaling in a PXR dependent manner.
Ginsenoside CK promotes the recovery of colitis induced by dextran sulfate sodium (DSS) by inhibiting NF - κ B activation. Ginsenoside CK significantly reduced the upregulation of IL-1 β and iNOS mRNA levels induced by TNF - α, and restored the mRNA levels of PXR and CYP3A4 in LS174T cells.
Ginsenoside CK is one of the intestinal metabolites of 20 (S) - protopanaxadiol derivatives, which has an inhibitory effect on the activity of CYP2C9 in human liver microsomes with an IC50 value of 32.0 ± 3.6 μ M. The inhibitory effect on CYP2A6 activity in human liver microsomes is weaker with an IC50 value of 63.6 ± 4.2 μ M, and the inhibitory effect on CYP2D6 activity in human liver microsomes is weaker with an IC50 value exceeding 100 μ M
Company Details
Business Type:
Manufacturer,Exporter,Seller
Year Established:
2016
Total Annual:
500,000-1000,000
Employee Number:
50~100
Ecer Certification：
Site Member
Zhongke Runxin (Suzhou) Biotechnology Co., Ltd. was established on June 8, 2016. It is located in the Suzhou Industrial Base of the National Biochemical Engineering Research Center (Beijing) of the Institute of Process Engineering, Chinese Academy of Sciences. It is a high-tech enterprise that integ... Zhongke Runxin (Suzhou) Biotechnology Co., Ltd. was established on June 8, 2016. It is located in the Suzhou Industrial Base of the National Biochemical Engineering Research Center (Beijing) of the Institute of Process Engineering, Chinese Academy of Sciences. It is a high-tech enterprise that integ...
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